Our group tries to understand how cellular and molecular systems interpret signals from their environment and adapt their behaviour as a consequence. We use detailed and quantitative computational models and simulations to reproduce and study cellular and molecular processes. The group also participates to the development of community services that facilitate research in computational systems biology.
For more information about our work, you can look at the description of some projects and Follow us on twitter
Two visitors from Sven Bergmann's lab arriving this week
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Andrea Prunotto studied Theoretical Physics in Torino (Italy) and got a PhD in Biochemistry at the University of Zürich (Switzerland). His research main focuses on the analysis of RNAseq data, exploring the inter-individual variance of cardiovascular-related traits induced by sustained pharmacological perturbations of the beta-adrenergic system, using inbred mouse strains as a model. In a second project he studies (again, via RNAseq data) the variation of the transcripts in human neuronal-cell lines with different CGG repeats length in the promoter region of the FMR1 gene at different cell-culture time, in order to test basic hypotheses about the onset of the fragile FXTAS syndrome. Andrea has been a member of the Swiss Institute of Bioinformatics since 2011. |
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Rico Ruedi studied physics at the Ecole Polytechnique Fédérale de Lausanne, Switzerland. He obtained his Ph.D. in 2009 for his work on the ground state energy of atoms and quantum dots, in Prof. Hervé Kunz's Chaos and Disorder Group. In Sven Bergmann's Computational Biology Group at the University of Lausanne, Rico studies the inclusion of metabolomic data in genome-wide association studies. |
If you are interested to work with us at the Babraham Institute, have a look at the proposed positions, for instance:
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Summer internship: Modelling Autophagy vesicle formation and release We are looking for a summer student to help us develop mathematical models describing the formation and release of autophagy vesicle in collaboration with experimental biologists. Starting date: ASAP. More information. |
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Summer internship: Further development of MELTING, a software to compute the stability of double strands nucleic acids We are looking for a summer student to help us further extend the MELTING software, and in particular: extend the calorimetrics tables, implement support for epigenetic marks and develop a GUI. Starting date: ASAP. More information. |
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PhD studentship: Systems Pharmacology Models of Druggable Targets and Disease Mechanisms We are looking for an exceptional PhD candidate to work on systems pharmacology models, as part of a collaboration between the Babraham Institute (BI, Le Novère), the European Bioinformatics Institute (EBI, Hermjakob) and the pharmaceutical company GlaxoSmithKline (GSK, Curucull-Sanchez). Starting date: October 2013. More information. |
Contact:
Le Novere Lab
Babraham Institute
Babraham Research Campus
Cambridge CB22 3AT
United-Kingdom.
e-mail: lenov[ AT ]babraham.ac.uk